While overstimulation of the CB1 receptor may lead to symptoms such as high blood pressure and abnormally high cholesterol levels, CBD is a CB1 antagonist, so it is not likely to cause such issues. Furthermore, the World Health Organization has recently issued a global report on CBD, claiming that it has a good safety profile and minimal adverse public health effects.
I would love to hear from anyone who has tried CBD oil for arthritis? Esp rheumatoid arthritis. Looking for more information for my mom. She’s never tried any form of THC, but is now willing to give it a try, without having to smoke anything. Just wondering if anyone can give me some info. Is CBD oil helping you? how much do you take? when do you take it? Thanks all

Hemplucid uses domestically sourced full-spectrum CBD to make this tincture. It includes a medium-chain triglyceride carrier MCT oil as part of the formula. This product contains terpenes and nearly undetectable levels of THC. The ingredients are all-natural, and they come from hemp plants that are bred for almost ten years to ensure a high level of cannabinoids. This product is certified as organic, and it does not contain GMOs.
Interestingly, over-activation of the endocannabinoid system, primarily via CB1 receptor activation, contributes to increased abdominal obesity (i.e., fat gain along the midsection), glucose uptake into adipocytes (fat cells), and insulin resistance in muscle tissue. This “metabolic dysfunction” sets up a vicious cycle whereby further insulin resistance in muscles and the liver increases abdominal obesity and further CB1 over-activation, resulting in greater food-seeking behavior, increased appetite, and increased body fat gain.
For those asking what she uses, I have only been using CBD for a couple weeks, and though I use it for anxiety and back pain, I’m already eating less and losing a little weight as well. I use American Indican(Blueberry OG), but I plan on trying gold Koi soon, because American Indican doesn’t taste too good as a vape, but you can use it as a tincture too, and it DOES taste pretty good that way. I’ve heard Koi brand is more suited to vape, though, and works the same(it can ALSO be used as an under-the-tongue drop, as with American Indican).
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.
I asked if he knew why CBD is so broadly effective. Could it be a gigantic, all-purpose placebo? He shook his head. His theory is that it’s an essential nutrient, like vitamins and amino acids, and when there’s a deficiency of CBD, people get sick. Because CBD brings the body into homeostasis, or balance, it can work in two directions: cutting appetite in people who over-eat, and increasing appetite in those who need to eat more.
Another study published in 2012 by Farrimond et al. examining the effects of different phytocannabinoids, such as cannabinol (CBN) and CBD, on feeding patterns in rats supports the theory that different cannabinoids modulate CB1 receptors and enhance appetite and metabolism with opposing effects. This study demonstrated that cannabinol increased food intake and body weight gain, while CBD decreased food consumption and weight gain. If your guess is that in this study CBD was also working by “tanning” WAT to BAT, then you are likely spot on.
Furthermore, a study published in the Journal of Neuroendocrinology has suggested that the ECS is capable of stimulating specific areas of the body involved in metabolism, such as the skeletal muscles and GI tract. This happens due to the presence of anandamide and 2-AG, which are two naturally-occurring compounds in the body that interact with the CB1 and CB2 receptors.
To briefly review, the endocannabinoid system (ECS) is a group of specialized fatty acid-based signaling chemicals (think “keys”), their receptors (think “locks”), and the metabolic enzymes that produce and break them down. These endocannabinoid chemical signals act on similar brain and immune cell receptors (CB1 and CB2) using the active compounds found in cannabis – cannabidiol (CBD), and Δ9-tetrahydrocannabinol (THC).
The Hemp plant CBD oil is legal in almost all states, as it contains less than 0.3% THC and will not get you high. It is not the same as regular marijuana base CBD that is illegal in a lot of states due to it having a high THC %. I get Pure High Quality Hemp CBD from a really good company that keeps up with and follows the laws of each state. Only state at this time they cannot ship to is NE.
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.
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