CBD’s effect on homeostasis is believed to be why those in need of nutrition can experience an appetite increase and those with excess weight can experience an appetite decrease. The reason for this is that CBD is an adaptogen. Referred to by some scientists as “the boy scout molecule” because it always does the right thing in any given situation. The Journal of  Psychopharmacology tested this theory on rats in 2012. The researchers wanted to see how three common cannabinoids, including CBN, CBD, and CBG, affected the appetite of the rats. The study concluded that both CBD and CBG worked to reduce the rat’s appetite.
Collectively, these results stem from the ability of CBD to induce “fat browning” – that is, converting what is normally white-colored fat tissue (WAT-white adipose tissue) that stores energy to beige-colored fat tissue (BAT-brown and beige adipose tissue) that burns it. Previous studies have shown that boosting beige-colored fat in animals improves their glucose tolerance, making them more resistant to diabetes and various blood lipid abnormalities.

During a day at his office, I saw three patients who’d had success with CBD. The first was Sawyer Maddox, five, from Atlanta, who’d been diagnosed at three with a rare form of epilepsy, Doose Syndrome, which is resistant to medication. He was having more than 200 seizures a day, where he’d drop face first on the floor. His parents fitted him with a catcher’s mask for protection, and carpeted their home with foam to cushion his falls. The pediatric neurologist they saw in Atlanta gave him meds that made things worse. Desperate, the Maddoxes, a conservative Baptist family, flew to California to see Frankel. He started Sawyer on #1 oil, and three months later, the boy was seizure free.
Frankel puts his hand on his heart. “Imagine the pressure!” he says. A complex soul, whose parents survived the Holocaust, Frankel says that when his patients don’t get better, he’s sad and disappointed, and starts to question if he’s wasting people’s time and money. “But then ten people will get better, and I feel… grateful. It makes me confident I’m on the right road, on the right side of history.”
Scientists have only scraped the tip of the iceberg so far. The DEA has recently removed  CBD from its list of controlled substances. This significant event paves the way for government-funded grants that will allow some of the best minds in the world study cannabidiol’s effect on the human body. It will be exciting to see what is uncovered in the years to come. For the time being, evidence points to CBD’s use as a valuable tool for losing weight. And because it is safe and readily available in most places (check your own state to be sure), it is a simple way of supplementing your health as you attempt to shed unwanted pounds.
On symptoms like pain, CBD has a quick effect, as well as on anxiety etc. But, when you use it regularly and consistently you will notice an improvement in your homeostasis and your overall well-being.  Part of that is the improvement of your metabolism, as CBD does not only suppress excessive appetite but it improves your body’s fat burning mechanism.
Correcting a calorie excess with a calorie deficit sometimes works for weight loss, but it can be difficult. First of all, reducing calories leaves people feeling hungry, which can be incredibly uncomfortable. Second of all, weight gain can cause changes to hormone levels and balance, metabolic patterns, inflammation status, and balance within the endocannabinoid system.

Recent evidence from animal and human studies shows a role for the endocannabinoid system in maintaining energy balance and glucose as well as lipoprotein metabolism, according to a 2009 study. Modulation of this system has resulted in an improvement in a number of important risk factors in clinical trials, including visceral and subcutaneous abdominal adipose tissue, glucose tolerance, dyslipidemia and measures of inflammation.


This is likely why CBD is capable of stimulating appetite among people that are in dire need of nutrition (such as cancer patients on chemotherapy), while at the same time suppressing appetite in those who need to lose weight. The active compound helps keep the body in balance, so if you need weight gain it can help you improve your appetite, but if you are overweight, it may be able to help curb your desire to eat.
Another study published in 2012 by Farrimond et al. examining the effects of different phytocannabinoids, such as cannabinol (CBN) and CBD, on feeding patterns in rats supports the theory that different cannabinoids modulate CB1 receptors and enhance appetite and metabolism with opposing effects. This study demonstrated that cannabinol increased food intake and body weight gain, while CBD decreased food consumption and weight gain. If your guess is that in this study CBD was also working by “tanning” WAT to BAT, then you are likely spot on. 

When the endocannabinoid system becomes dysregulated, it often becomes overactive and too much fat is being stored, particularly in the intra-abdominal tissue. Cannabidiol is known to regulate the endocannabinoid system as it can restore balance in both directions. Therefore, the study concludes that, along with lifestyle changes cannabis could be a means of fighting obesity.
The previously mentioned study which established improved mitochondrial function with CBD use also observed that CBD stimulates gene expression within white fat cells. This initiates the “browning” of these cells. This mechanism shows promise with converting hard-to-lose white fat into a more easily burnable form. Additionally, researchers found that CBD decreased the rate of new fat cell creation.

Recent evidence from animal and human studies shows a role for the endocannabinoid system in maintaining energy balance and glucose as well as lipoprotein metabolism, according to a 2009 study. Modulation of this system has resulted in an improvement in a number of important risk factors in clinical trials, including visceral and subcutaneous abdominal adipose tissue, glucose tolerance, dyslipidemia and measures of inflammation.
Moreover, Murray Mittleman, an associate professor of medicine at Harvard Medical School, explained to Time Magazine in 2013 that weed users had lower fasting insulin levels and were less resistant to insulin produced by the body. He was referring to research from the National Health and Nutrition Examination Survey, which analyzed 4,600 men and women over a five year period from 2005 to 2010. 48% of them used cannabis at least once in their lives, and 12% were current users.

Cannabidiol (CBD) is one of over 100 phytocannabinoids found in marijuana and hemp plants. Together with tetrahydrocannabinol (THC), CBD is a cannabinoid intensely investigated for its health properties. Unlike THC, CBD is not psychoactive. This means that when CBD is consumed, it produces no psychological effects, or the controversial “high” marijuana is well known for.

The effects of slow metabolism stretch beyond impeding weight loss. It can cause high cholesterol, high blood pressure, high blood sugar, and chronic fatigue. There are many different kinds of metabolism support pills on the market, as well as pills and a myriad of other products to help you lose weight. Each of these come with their own problems: Do they work? What are the side effects? To avoid the guesswork, we recommend you try CBD for weight loss. When you decide to do so, there are two important things to consider.

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