Frankel grew plants, crossed strains, and tried them on friends as  well as himself. Working with chemists and professional growers, he  developed formulas for whole plant oils, which are manufactured  independently and for which he receives no compensation. In 2006,  Frankel felt he’d learned enough to open a new practice as a cannabis  medical consultant.

Furthermore, a study published in the Journal of Neuroendocrinology has suggested that the ECS is capable of stimulating specific areas of the body involved in metabolism, such as the skeletal muscles and GI tract. This happens due to the presence of anandamide and 2-AG, which are two naturally-occurring compounds in the body that interact with the CB1 and CB2 receptors.
Moreover, Murray Mittleman, an associate professor of medicine at Harvard Medical School, explained to Time Magazine in 2013 that weed users had lower fasting insulin levels and were less resistant to insulin produced by the body. He was referring to research from the National Health and Nutrition Examination Survey, which analyzed 4,600 men and women over a five year period from 2005 to 2010. 48% of them used cannabis at least once in their lives, and 12% were current users.
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CBD interacts with the body’s endocannabinoid system; this system exists to keep our bodies in balance. Most of the time when someone is overweight there is one main culprit that leads to them struggling with weight loss: metabolism. Metabolism and weight loss are very connected because your metabolism is what converts food into energy in the body. It’s also responsible for the body’s ability to burn calories and the rate at which it does so.
On the plus side, there is an earnest desire for people to lose weight, which is why the weight loss industry is worth an astonishing $66 billion! But this staggering number, added to the fact that fewer people are dieting and more are gaining weight, tells us two things: One, that weight loss supplements are fundamentally ineffective; and two, that they are very, very expensive.
The endocannabinoid system appears to have an essential role in regulating basic human functions like sleep, eating, metabolism, and more. When this system is not functioning correctly, weight gain can occur. CBD helps to restore homeostasis to the cells of the body and can be very useful in reducing fat accumulation and subsequent health risks related to excess body weight.
Frankel also asserts that CBD reduces appetite—the opposite of THC, which triggers hedonic over-eating. I hadn’t read this anywhere, so I invited two friends, Tina and Cha Cha, to try it with me. We would soon be calling ourselves the Ladies Weed Detective Society. We squeezed a few drops of CBD-infused oil under our tongues and waited. An hour later, at the time we’d planned to have dinner, we noticed we weren’t especially hungry. All thoughts of food had been swept away. If this effect were widely known, Tina said, “Cannabis would be legal in twenty minutes.”
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.
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