In 2013, a team of four medical researchers lead by Dr. Elizabeth Penner MD, MPH, carried out a clinical study with over 4,500 participants, called “The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults”. They concluded: “We found that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference.”
To briefly review, the endocannabinoid system (ECS) is a group of specialized fatty acid-based signaling chemicals (think “keys”), their receptors (think “locks”), and the metabolic enzymes that produce and break them down. These endocannabinoid chemical signals act on similar brain and immune cell receptors (CB1 and CB2) using the active compounds found in cannabis – cannabidiol (CBD), and Δ9-tetrahydrocannabinol (THC).
Furthermore, a study published in the Journal of Neuroendocrinology has suggested that the ECS is capable of stimulating specific areas of the body involved in metabolism, such as the skeletal muscles and GI tract. This happens due to the presence of anandamide and 2-AG, which are two naturally-occurring compounds in the body that interact with the CB1 and CB2 receptors.
Frankel runs GreenBridge Medical, which he founded in 2006, like an internist’s office. He begins with a one-hour consult, comes up with a treatment plan, and recommends products for which he designed the formulas: ten oils with different combinations of THC and CBD. (THC gets you high; CBD doesn’t, but is alleged to have strong healing properties) The #1 oil is almost all CBD, #10 is almost all THC, and #5 has equal amounts of both. So the doctor, patient, and dispensary know how many milligrams of what chemicals the patient is taking, and the doctor can adjust the dose as needed.
Frankel grew plants, crossed strains, and tried them on friends as well as himself. Working with chemists and professional growers, he developed formulas for whole plant oils, which are manufactured independently and for which he receives no compensation. In 2006, Frankel felt he’d learned enough to open a new practice as a cannabis medical consultant.
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.
The CB1 receptors are mostly present in the brain, but some are located throughout your body. These receptors deal with movement and coordination, emotions, thinking, memories, pain, mood, appetite, and other function. The CB2 receptors are mostly in the immune system. They affect pain and inflammation. CBD works in two ways. It attaches itself to these receptors while stimulating the body to produce more cannabinoids on its own naturally. Amazingly, CBD assists the body in learning to heal itself.

In 2007, he was investigated by the California Medical Board and in 2008, his license to practice was suspended. He fought this in court, losing his house to pay legal bills, and in 2011, his license was reinstated. During those “hard years,” he said, he hired other doctors to write recommendations for medical marijuana licenses, then Frankel advised the patients how to treat their ailments. “I could have quit and taken a job that paid well, but I kept asking myself, what’s the best thing I can do for my patients?” He thought about what his parents had suffered in Auschwitz. “Why should I crumble because the medical board takes away a piece of paper? I was willing to fight for something I feel is absolutely good—because of its efficacy and lack of side effects.”
Another study published in 2012 by Farrimond et al. examining the effects of different phytocannabinoids, such as cannabinol (CBN) and CBD, on feeding patterns in rats supports the theory that different cannabinoids modulate CB1 receptors and enhance appetite and metabolism with opposing effects. This study demonstrated that cannabinol increased food intake and body weight gain, while CBD decreased food consumption and weight gain. If your guess is that in this study CBD was also working by “tanning” WAT to BAT, then you are likely spot on.
Scam CBD sellers tend to manufacture low-grade oils via ethanol (or other solvent-based) extraction, in what is little better than trying to do it yourself in your basement. The result is a liquid that contains a little CBD (along with some other cannabinoids and terpenes), but not in the quantities needed to be effective in terms of any legitimate medicinal function. Moreover, these solvent-based extracts can contain unnecessary and potentially harmful components.
In 2007, he was investigated by the California Medical Board and in 2008, his license to practice was suspended. He fought this in court, losing his house to pay legal bills, and in 2011, his license was reinstated. During those “hard years,” he said, he hired other doctors to write recommendations for medical marijuana licenses, then Frankel advised the patients how to treat their ailments. “I could have quit and taken a job that paid well, but I kept asking myself, what’s the best thing I can do for my patients?” He thought about what his parents had suffered in Auschwitz. “Why should I crumble because the medical board takes away a piece of paper? I was willing to fight for something I feel is absolutely good—because of its efficacy and lack of side effects.”

The increased activity of the pancreas in an attempt to secrete additional insulin can cause inflammation throughout the gland. That chronic inflammation can actually destroy the beta cells which are the sites that secrete insulin. This downward spiral diminishes the body’s ability to make insulin at all – a dangerous path that can lead to diabetes.


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Moreover, the inconsistency (to put it mildly) of the weight loss industry is probably more sketchy and less regulated than the current state of the cannabis industry. Google ‘weight loss scams,’ for instance, and you’ll get 5.76 million search results! There have been some shocking scams over the years, including vibration machines, weight loss pills (containing poisons such as arsenic), and ‘Vision-Dieter Glasses,’ just to name a few.
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.
While overstimulation of the CB1 receptor may lead to symptoms such as high blood pressure and abnormally high cholesterol levels, CBD is a CB1 antagonist, so it is not likely to cause such issues. Furthermore, the World Health Organization has recently issued a global report on CBD, claiming that it has a good safety profile and minimal adverse public health effects.

The previously mentioned study which established improved mitochondrial function with CBD use also observed that CBD stimulates gene expression within white fat cells. This initiates the “browning” of these cells. This mechanism shows promise with converting hard-to-lose white fat into a more easily burnable form. Additionally, researchers found that CBD decreased the rate of new fat cell creation.
Before using CBD for weight loss, it is vital to ensure that you are using a quality product, as this has a significant impact on how much it can aid you in losing weight and maintaining what you lose. A company using domestically sourced organic hemp that has been grown in clean soil is your best choice. You also want to make sure third-party lab testing is done on a regular basis and that the extraction methods used in the manufacturing process are clean and solvent-free.
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