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Interestingly, over-activation of the endocannabinoid system, primarily via CB1 receptor activation, contributes to increased abdominal obesity (i.e., fat gain along the midsection), glucose uptake into adipocytes (fat cells), and insulin resistance in muscle tissue. This “metabolic dysfunction” sets up a vicious cycle whereby further insulin resistance in muscles and the liver increases abdominal obesity and further CB1 over-activation, resulting in greater food-seeking behavior, increased appetite, and increased body fat gain.


Frankel had rarely tried cannabis until he was 49. He was a partner in one of the most successful practices in West Los Angeles and a clinical professor at UCLA Medical School. He’d been my family’s internist for 15 years, and I found him a skilled diagnostician, who listened carefully, and who cared. He had to quit practicing in 2000, after he’d suffered a disabling back injury, then developed a viral infection of the heart and was told he had six months to live. Some of his cancer and AIDS patients urged him to try cannabis. “They did a reverse intervention,” he said, and a year later, his heart was normal. He can’t be certain how or if cannabis healed his heart. “I’d been depressed and CBD stopped the depression,” he said. “It gave me something to look forward to. My brain was turned on.”
Hi Alda, I found this article while looking for reasons why my appetite was suppressed and had a feeling it was the CBD I am using. I’ve always been a big guy with a big appetite and now have to force myself to eat and cannot finish large meals like in the past. Hunger no longer controls my life. I started with cbd oil earlier this year in March and now use high CBD low THC (less than .3%) flower in a vaporizer. I went from 275 to 255 since March with no changes in my physical activity. Now that I have my appetite under control I can focus on getting in the gym.
Jennifer Kurtz studied medicine at the New Jersey School of Medicine (Rutgers). She is passionate about developing her knowledge of Cannabis, Nootropics, Kratom, and nutritional supplements. In addition to attending medical webinars and conferences, she loves to write research-based articles for magazines, healthcare professionals, and medical agencies.
Frankel grew plants, crossed strains, and tried them on friends as  well as himself. Working with chemists and professional growers, he  developed formulas for whole plant oils, which are manufactured  independently and for which he receives no compensation. In 2006,  Frankel felt he’d learned enough to open a new practice as a cannabis  medical consultant.

When the endocannabinoid system becomes dysregulated, it often becomes overactive and too much fat is being stored, particularly in the intra-abdominal tissue. Cannabidiol is known to regulate the endocannabinoid system as it can restore balance in both directions. Therefore, the study concludes that, along with lifestyle changes cannabis could be a means of fighting obesity.
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