Interestingly, over-activation of the endocannabinoid system, primarily via CB1 receptor activation, contributes to increased abdominal obesity (i.e., fat gain along the midsection), glucose uptake into adipocytes (fat cells), and insulin resistance in muscle tissue. This “metabolic dysfunction” sets up a vicious cycle whereby further insulin resistance in muscles and the liver increases abdominal obesity and further CB1 over-activation, resulting in greater food-seeking behavior, increased appetite, and increased body fat gain.
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Moreover, the inconsistency (to put it mildly) of the weight loss industry is probably more sketchy and less regulated than the current state of the cannabis industry. Google ‘weight loss scams,’ for instance, and you’ll get 5.76 million search results! There have been some shocking scams over the years, including vibration machines, weight loss pills (containing poisons such as arsenic), and ‘Vision-Dieter Glasses,’ just to name a few.
I’m glad you’ve found help from CBD products, James. I’ve been told by many pros that without any THC, the CBDs are not activated and so you’re essentially not getting hardly any benefit. Or you might need more of the product to get benefit. So I might suggest looking into this and trying a tincture that’s a 20/1 CBD/THC ratio. You won’t feel the THC effects but you’ll get the full benefit the plant has to offer.
The CB1 receptors are mostly present in the brain, but some are located throughout your body. These receptors deal with movement and coordination, emotions, thinking, memories, pain, mood, appetite, and other function. The CB2 receptors are mostly in the immune system. They affect pain and inflammation. CBD works in two ways. It attaches itself to these receptors while stimulating the body to produce more cannabinoids on its own naturally. Amazingly, CBD assists the body in learning to heal itself.
On symptoms like pain, CBD has a quick effect, as well as on anxiety etc. But, when you use it regularly and consistently you will notice an improvement in your homeostasis and your overall well-being. Part of that is the improvement of your metabolism, as CBD does not only suppress excessive appetite but it improves your body’s fat burning mechanism.
With all of the information inundating the internet about CBD oil, many people are curious, can CBD help with weight loss? A study done in 2012 documented the way that cannabinol and cannabidiol affected the feeding patterns in rats. After dosing rats with CBD, the scientists observed that they ate less; this set the stage for more research to be done to continue to show the weight loss opportunities with CBD. It also brought into light a new use for CBD as an appetite suppressant. In addition to that, a report in India Times in 2016 said that cannabis users show a lower rate of obesity and diabetes. Science has also demonstrated links between the use of cannabis and metabolism for many years.
While overstimulation of the CB1 receptor may lead to symptoms such as high blood pressure and abnormally high cholesterol levels, CBD is a CB1 antagonist, so it is not likely to cause such issues. Furthermore, the World Health Organization has recently issued a global report on CBD, claiming that it has a good safety profile and minimal adverse public health effects.
For those asking what she uses, I have only been using CBD for a couple weeks, and though I use it for anxiety and back pain, I’m already eating less and losing a little weight as well. I use American Indican(Blueberry OG), but I plan on trying gold Koi soon, because American Indican doesn’t taste too good as a vape, but you can use it as a tincture too, and it DOES taste pretty good that way. I’ve heard Koi brand is more suited to vape, though, and works the same(it can ALSO be used as an under-the-tongue drop, as with American Indican).
Frankel grew plants, crossed strains, and tried them on friends as well as himself. Working with chemists and professional growers, he developed formulas for whole plant oils, which are manufactured independently and for which he receives no compensation. In 2006, Frankel felt he’d learned enough to open a new practice as a cannabis medical consultant.
Populum’s CBD oil utilizes a full-spectrum of cannabinoids. It has a subtle orange flavor and contains antioxidants, natural ingredients, and neuroprotectants. It is free from GMOs and gluten. The label shows that this product is made with several oils in addition to hemp oil, including grapeseed, orange, and virgin coconut oils. It also contains stevia extract for a sweet flavor.
He did exhaustive research. He found there’d been decades of scientific studies on the effects of THC and CBD on cells and animals, but few trials with humans, because the FDA classifies cannabis and all its components as Schedule 1 drugs, which have “no accepted medical treatment use.” It took Sue Sisley, an Arizona physician, seven years of struggling with bureaucratic hurdles before she received the first FDA approval for a study, just beginning, of marijuana with vets who have PTSD.
Another study published in 2012 by Farrimond et al. examining the effects of different phytocannabinoids, such as cannabinol (CBN) and CBD, on feeding patterns in rats supports the theory that different cannabinoids modulate CB1 receptors and enhance appetite and metabolism with opposing effects. This study demonstrated that cannabinol increased food intake and body weight gain, while CBD decreased food consumption and weight gain. If your guess is that in this study CBD was also working by “tanning” WAT to BAT, then you are likely spot on.
I asked if he knew why CBD is so broadly effective. Could it be a gigantic, all-purpose placebo? He shook his head. His theory is that it’s an essential nutrient, like vitamins and amino acids, and when there’s a deficiency of CBD, people get sick. Because CBD brings the body into homeostasis, or balance, it can work in two directions: cutting appetite in people who over-eat, and increasing appetite in those who need to eat more.