But, if you are heavily obese you most probably will start with a much higher dosage. In order to find the right dosage for your situation, you can start with a relatively moderate level and, monitor for two weeks, increase, monitor etc. etc. Start with 60mg a day divided into three (or two) takings and see how much weight you lost during a two-week period.
In 2007, he was investigated by the California Medical Board and in 2008, his license to practice was suspended. He fought this in court, losing his house to pay legal bills, and in 2011, his license was reinstated. During those “hard years,” he said, he hired other doctors to write recommendations for medical marijuana licenses, then Frankel advised the patients how to treat their ailments. “I could have quit and taken a job that paid well, but I kept asking myself, what’s the best thing I can do for my patients?” He thought about what his parents had suffered in Auschwitz. “Why should I crumble because the medical board takes away a piece of paper? I was willing to fight for something I feel is absolutely good—because of its efficacy and lack of side effects.”
The increased activity of the pancreas in an attempt to secrete additional insulin can cause inflammation throughout the gland. That chronic inflammation can actually destroy the beta cells which are the sites that secrete insulin. This downward spiral diminishes the body’s ability to make insulin at all – a dangerous path that can lead to diabetes.
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease. 
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