In 2013, a team of four medical researchers lead by Dr. Elizabeth Penner MD, MPH, carried out a clinical study with over 4,500 participants, called “The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults”. They concluded: “We found that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference.”

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During a day at his office, I saw three patients who’d had success with CBD. The first was Sawyer Maddox, five, from Atlanta, who’d been diagnosed at three with a rare form of epilepsy, Doose Syndrome, which is resistant to medication. He was having more than 200 seizures a day, where he’d drop face first on the floor. His parents fitted him with a catcher’s mask for protection, and carpeted their home with foam to cushion his falls. The pediatric neurologist they saw in Atlanta gave him meds that made things worse. Desperate, the Maddoxes, a conservative Baptist family, flew to California to see Frankel. He started Sawyer on #1 oil, and three months later, the boy was seizure free.
In 2007, he was investigated by the California Medical Board and in 2008, his license to practice was suspended. He fought this in court, losing his house to pay legal bills, and in 2011, his license was reinstated. During those “hard years,” he said, he hired other doctors to write recommendations for medical marijuana licenses, then Frankel advised the patients how to treat their ailments. “I could have quit and taken a job that paid well, but I kept asking myself, what’s the best thing I can do for my patients?” He thought about what his parents had suffered in Auschwitz. “Why should I crumble because the medical board takes away a piece of paper? I was willing to fight for something I feel is absolutely good—because of its efficacy and lack of side effects.”
Furthermore, a study published in the Journal of Neuroendocrinology has suggested that the ECS is capable of stimulating specific areas of the body involved in metabolism, such as the skeletal muscles and GI tract. This happens due to the presence of anandamide and 2-AG, which are two naturally-occurring compounds in the body that interact with the CB1 and CB2 receptors.
Correcting a calorie excess with a calorie deficit sometimes works for weight loss, but it can be difficult. First of all, reducing calories leaves people feeling hungry, which can be incredibly uncomfortable. Second of all, weight gain can cause changes to hormone levels and balance, metabolic patterns, inflammation status, and balance within the endocannabinoid system.

Due to the uniqueness of everyone’s endocannabinoid system, CBD does not affect any two people the same way. There are a host of factors that influence its efficacy, including genetics, previous history of use, general health, weight, ethnicity and so on. Therefore, while one person may find that 15 mg of CBD a day works wonders for suppressing appetite and boosting weight loss, another may require up to 100 mg (or more) in order to achieve the same results (or they may not experience any results at all).


To briefly review, the endocannabinoid system (ECS) is a group of specialized fatty acid-based signaling chemicals (think “keys”), their receptors (think “locks”), and the metabolic enzymes that produce and break them down. These endocannabinoid chemical signals act on similar brain and immune cell receptors (CB1 and CB2) using the active compounds found in cannabis – cannabidiol (CBD), and Δ9-tetrahydrocannabinol (THC).
Another study published in 2012 by Farrimond et al. examining the effects of different phytocannabinoids, such as cannabinol (CBN) and CBD, on feeding patterns in rats supports the theory that different cannabinoids modulate CB1 receptors and enhance appetite and metabolism with opposing effects. This study demonstrated that cannabinol increased food intake and body weight gain, while CBD decreased food consumption and weight gain. If your guess is that in this study CBD was also working by “tanning” WAT to BAT, then you are likely spot on.
Moreover, the inconsistency (to put it mildly) of the weight loss industry is probably more sketchy and less regulated than the current state of the cannabis industry. Google ‘weight loss scams,’ for instance, and you’ll get 5.76 million search results! There have been some shocking scams over the years, including vibration machines, weight loss pills (containing poisons such as arsenic), and ‘Vision-Dieter Glasses,’ just to name a few.
While overstimulation of the CB1 receptor may lead to symptoms such as high blood pressure and abnormally high cholesterol levels, CBD is a CB1 antagonist, so it is not likely to cause such issues. Furthermore, the World Health Organization has recently issued a global report on CBD, claiming that it has a good safety profile and minimal adverse public health effects.

First of all, we have to bring it to your attention that there are CBD oil scams out there. However, the unscrupulous companies involved in these schemes don’t use high-quality CBD in their products. Pure CBD oil of the highest quality is extracted from industrial hemp via CO2 extraction, and such organizations that use quality oil also include independent third-party lab testing results of their products to guarantee both purity and content.

Also, please note that CBD should NOT be misunderstood as a miracle cure — and no reputable CBD seller or manufacturer should ever claim otherwise. Furthermore, if you are using CBD for weight loss purposes, don’t expect it to work if you eat fast food three times a day and your exercise routine consists of struggling to twist the cap off your bottle of beer!
Another marker of obesity and diabetes includes damage to liver cells. The liver is a major organ in the conversion between stored energy forms and useable energy forms in the body. Overburdening that system, such as with high fructose intake, can have disastrous effects. Inflammation within the liver indicates the onset of dysfunction, and possibly non-alcoholic fatty liver disease.

For those asking what she uses, I have only been using CBD for a couple weeks, and though I use it for anxiety and back pain, I’m already eating less and losing a little weight as well. I use American Indican(Blueberry OG), but I plan on trying gold Koi soon, because American Indican doesn’t taste too good as a vape, but you can use it as a tincture too, and it DOES taste pretty good that way. I’ve heard Koi brand is more suited to vape, though, and works the same(it can ALSO be used as an under-the-tongue drop, as with American Indican).
The next two patients were women, Brigitte Bedi, a slim, blonde yoga teacher, who suffered severe brain damage in a car crash, and Tanya Lynn, from Canada, who had myasthenia gravis (MG), an autoimmune disease that weakens the face and throat muscles, so it’s hard to speak, swallow and breathe. Both had been given meds by their doctor that caused unpleasant side effects, and had been told they would not get any better. Frankel treated them with different cannabinoid oils, and within 12 to 18 months, both were better and leading normal lives.
Since I started useing medicinal CBD oil in a vaporizer to treat my fibromialgia pain I have lost 40 pounds of fat without changing anything I’m doing. It controls my hunger and my mood which stopped me from bing eating. It gave me energy to do more without pain as well as clearing up a skin problem I was having that my dermatologist tried every pharmaceutical cream on the market. It took cannabis an illegal product to fix me.
I asked if he knew why CBD is so broadly effective. Could it be a gigantic, all-purpose placebo? He shook his head. His theory is that it’s an essential nutrient, like vitamins and amino acids, and when there’s a deficiency of CBD, people get sick. Because CBD brings the body into homeostasis, or balance, it can work in two directions: cutting appetite in people who over-eat, and increasing appetite in those who need to eat more.

I’m glad you’ve found help from CBD products, James. I’ve been told by many pros that without any THC, the CBDs are not activated and so you’re essentially not getting hardly any benefit. Or you might need more of the product to get benefit. So I might suggest looking into this and trying a tincture that’s a 20/1 CBD/THC ratio. You won’t feel the THC effects but you’ll get the full benefit the plant has to offer.
To briefly review, the endocannabinoid system (ECS) is a group of specialized fatty acid-based signaling chemicals (think “keys”), their receptors (think “locks”), and the metabolic enzymes that produce and break them down. These endocannabinoid chemical signals act on similar brain and immune cell receptors (CB1 and CB2) using the active compounds found in cannabis – cannabidiol (CBD), and Δ9-tetrahydrocannabinol (THC).
The effects of slow metabolism stretch beyond impeding weight loss. It can cause high cholesterol, high blood pressure, high blood sugar, and chronic fatigue. There are many different kinds of metabolism support pills on the market, as well as pills and a myriad of other products to help you lose weight. Each of these come with their own problems: Do they work? What are the side effects? To avoid the guesswork, we recommend you try CBD for weight loss. When you decide to do so, there are two important things to consider.
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